Pro-tumorigenic Effects of Transforming Growth Factor Beta 1 in Canine Osteosarcoma
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منابع مشابه
Pro‐tumorigenic Effects of Transforming Growth Factor Beta 1 in Canine Osteosarcoma
BACKGROUND Transforming growth factor beta 1 (TGFβ1) is a pleiotropic cytokine that contributes to reparative skeletal remodeling by inducing osteoblast proliferation, migration, and angiogenesis. Organic bone matrix is the largest bodily reservoir for latent TGFβ1, and active osteoblasts express cognate receptors for TGFβ1 (TGFβRI and TGFβRII). During malignant osteolysis, TGFβ1 is liberated f...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 2014
ISSN: 0891-6640
DOI: 10.1111/jvim.12348